发给老马备查:' V. ^9 n1 T. c. o
滴水察海(69304838) 15:23:23: A8 c, _) G( b u
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱/ f5 d& Z7 G; T( U6 h' C! f
吉非替尼和S-1连用的依据
2 ?& `' h: Y( uGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
* z- _1 |, l) v) M4 C" r9 I是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
, Y) m8 P/ X8 h' p. }4 P这样是不是推理出,耐药后,可以用S-1和培美了?
! ^) t) i+ R$ `1 z+ |结论:
; q- O: V3 S* ~. v如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |