发给老马备查:! _) Y' s' X6 V1 u! w
滴水察海(69304838) 15:23:23
2 A4 e: v9 o# I) c) ? b+ y! O老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱) ]/ k# X7 n. i* r! C
吉非替尼和S-1连用的依据) g- X6 O% U6 v# I/ N
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
+ L, r$ ? W! E, q O是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达* y; J5 s B4 d* ]# J J5 q, `
这样是不是推理出,耐药后,可以用S-1和培美了?; U8 Q$ t' A! w
结论:
7 G8 E/ E, A, \9 F- w8 D8 D如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |