发给老马备查:/ W. I( G2 ~4 ]6 G
滴水察海(69304838) 15:23:23$ J6 U) F6 _) v8 _' x# k% O) W
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
! ~9 W! j. G8 b% A1 \& p) j2 _吉非替尼和S-1连用的依据( {# O i; o5 l% M2 K2 J
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
, [$ u) Y2 | o/ b是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
5 I% N/ k8 @+ t; P: |" ?% b这样是不是推理出,耐药后,可以用S-1和培美了? l* g6 e7 i( u+ {- D9 X
结论:
& H5 J2 @8 Y4 O% V. Z2 R如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |