发给老马备查:, p2 u/ p/ q5 H/ r* l
滴水察海(69304838) 15:23:23
( P. Q& M/ }0 A' Y! m& K+ D老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱$ O7 O, H/ ^5 |( \6 c/ R
吉非替尼和S-1连用的依据
7 r9 @% r: a$ K9 H9 d' S) YGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.& {- v( a- B! ]7 c7 q/ T
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达! f C# H3 h1 H" [0 n8 n" X
这样是不是推理出,耐药后,可以用S-1和培美了?6 P; ?( p* K/ I" ?0 f! f* `
结论:
* {! t. z8 H! _, \0 T1 C如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |