看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。
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Currently available feasibility data for possible combination strategies. 3 O$ o/ e+ \% U: U6 ^- K& c
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& U- h5 R3 ?: J* YCombination Feasibility according to preliminary data 0 W& j f O, p" U8 A$ R% d
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1 |# l- R) U' |- b3 jBevacizumab + sorafenib Yes, reduced dose & m9 {0 l* o8 V3 v
Bevacizumab + sunitinib† No / H6 @; N4 r) c }" |& t
Bevacizumab + temsirolimus Yes
. y3 D5 r) S" {2 RBevacizumab + everolimus Yes ' r y5 R& F: ]6 P! U6 h$ c
Sorafenib + sunitinib ? _# R& v3 e. L3 B/ P+ x1 u6 ?
Sorafenib + temsirolimus Yes, reduced dose
! v0 n+ Z4 x: c6 I" x, s6 s2 [Sorafenib + everolimus Yes, reduced dose
9 V: D, r6 `0 K Q# q \( gSunitinib + temsirolimus† No
) K9 Y, K! H: b0 _$ k4 R1 eSunitinib + everolimus ?
9 q; b% T4 _- D9 p' s+ b: ~Temsirolimus + everolimus ? 7 t( S3 u2 |9 t
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$ o7 w- {8 y3 A†Led to US FDA warning.
: A- F0 \7 V9 `) M- a?: As yet unattempted combination.. J6 ]$ u. d0 f- T
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